At Arch Oncology, we are aiming high to discover and develop new antibody therapeutics to treat patients living with cancer. We are committed to advancing antibodies with best-in-class potential.
Our next-generation anti-CD47 antibodies are highly differentiated, with the potential to improve upon the safety and efficacy profile relative to other agents in this class. Our antibodies work by blocking the “don’t eat me” signal, the standard mechanism of anti-CD47 antibodies. Beyond blocking this signal, our antibodies also directly kill tumor cells. Importantly, our antibodies bind preferentially to tumor cells, instead of to normal cells, and bind even more potently to tumors in their acidic microenvironment (low pH).
Expanding our fight against cancer, we are advancing our lead anti-CD47 antibody AO-176 into clinical development for the treatment of patients with solid tumors.
We are aiming high in our fight against cancer. We are a team of highly experienced and driven professionals who are committed to excellence in all that we do. Our leadership team has successfully developed new drugs before. We know what we need to do to collaborate and execute to get the job done.
If you share this commitment and want to work with a team that is focused on helping patients, come aim high with us and apply.
The Arch Oncology research labs are located in the Cortex Innovation Community in St. Louis, MO, near the Washington University School of Medicine and St. Louis University. Arch Oncology also has offices in the San Francisco Bay Area, CA. This position will be located in St. Louis.
Senior Scientist, Research
JOB DESCRIPTION AND RESPONSIBILITIES
- Design and perform a variety of in vitro cell based assay experiments with tumor and immune cells to demonstrate functional characterisitics of antibodies.
- Perform other standard molecular, biochemical and biologic techniques associated with in vitro characterization of anti-cancer antibodies (ex. Flow cytometry, ELISA, Western Blotting, Cloning etc.).
- Identify and initiate development of potential biomarker assays for translation to clinical studies.
- Evaluate potential CROs for assay development capabilities and work with translational medicine to transfer assays to CRO for further development and validation.
- Interface with the translational team to ensure study alignment with clinical path.
- Present at laboratory group meetings and external scientific meetings and provide. materials/slides for other scientists at project presentations.
- Maintain a command of relevant scientific literature.
- Maintain thorough and accurate scientific records.
- The expected balance between lab and office duties is 75:25 respectively.
POSITION REQUIREMENTS AND EXPERIENCE
- Ph.D. with recent postdoctoral experience in cancer biology, pharmacology, immunology, translational medicine or Postdoc with 1-2 years of industry-related experience. Industry experience is a plus, but not firmly required.
- Strong scientific knowledge and research experience in cancer biology/immuno-oncology and experience with antibodies preferred but not absolutely required.
- Demonstrated excellence in experimental design, troubleshooting, and data analysis skills.
- Strong collaborative skills; well-organized; goal oriented; effective in a multidisciplinary team environment.
- A strong work ethic, drive, pro-activeness and ability to execute and multi-task activities with minimal supervision.
- Strong problem-solving and analytical skills.
- Ability to work independently in a fast-pace environment.
- Excellent written and verbal communication skills.
- Exemplifies honesty, ethics, and integrity.
Arch Oncology is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Please send your CV and cover letter to